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Spend your Saturday afternoon with a gang of ladies and dudes stripped down to their drawers (undies are encouraged, but not mandatory, FYI), running a mile-ish trek through the streets of DTLA to raise money for the neurofibromatosis-fighting non-profit. Why in your undies, you might ask? As the site explains, "...because people with NF can't cover up their tumors. They can't put clothes on to feel more comfortable, so why should we?" Register here (it'll cost you $55) and join the panty party starting at noon at the iconic Belsco Theater.